To evaluate the hepatoprotective activity of Pterospermum acerifolium leafextract against carbon tetrachloride induced hepatotoxicity in vivo and also evaluate free radical scavenging activity in-vitro. The present study was undertaken to evaluate the protective effect of Pterospermum acerifolium leaf extract on carbon tetrachloride induced hepatotoxicity and to elucidate the possible mechanism that underlines above effect in rat. Analyzed parameters included serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT), alkaline phosphatase (ALP) and total bilirubin. The active oxygen scavenging activity or free radical scavenging activity, hydroxyl radical scavenging activity and super oxide scavenging activity were also investigated. Pterospermum acerifolium leaf extract exhibited significant hepatoprotective activity as well as free radical scavenging activity by inhibiting DPPH (1,1-diphenyl-2picryl hydrazyl ) , Nitric oxide and Hydroxyl radical Pterospermum acerifolium leaves extract showed hepatoprotective as well as dose dependent free radical scavenging activity in all model.
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